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ACTA Pharmaceutica Sciencia
2009 , Vol 51 , Num 3
PREPARATION AND IN VITRO EVALUATION OF INDOMETHACIN LOADED SOLID LIPID MICROPARTICLES
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In this study, solid lipid microparticles of indomethacin have been formulated using Tween® 80, Labrasol® and Sucroester® WE15 in combination with Compritol® 888 ATO. ATR-FTIR spectroscopic studies and SEM results showed that lipid dispersions and microparticles of indomethacin were highly in amorphous form controversially in contrast to indomethacin crystal form. Particle size distribution analysis showed that indomethacin loaded lipid particles had a particle size distribution in the micron range. In vitro drug release studies indicated that indomethacin release is prolonged when Sucroester® WE15 used as surfactant and type of the surfactant was found to affect the dissolution rate of indomethacin.
Keywords :
LIPID MICROPARTICLES, GLYCERYL BEHENATE, SUCROSE ESTER, LABRASOL®, TWEEN 80®