ACTA Pharmaceutica Sciencia 2007 , Vol 49 , Num 1
EFFECT OF VEHICLES ON IN VITRO RELEASE OF METRONIDAZOLE THROUGH DIFFERENT MEMBRANES
MİNE ÖZYAZICI, ESRA BALOĞLU, SİNEM Y KARAVANA, ÖZGEN ÖZER, TAMER GÜNERİ
Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, Turkey. The invitro release tests is a measure of inprocess control and also as a finished product specification for creams, ointments and gels. The objective of this study was to evaluate the in vitro release and ex-vivo percutaneous absorption of Metronidazole (MTD) from different water soluble and oleaginous vehicles. All of the experiments were conducted using three different barriers (synthetic membrane, excised rat and rabbit skins). Within the barriers tested rat skin was found to be the best alternative to the others. Moreover water soluble vehicles could be suggested as good candidates for the topical delivery of MTD, giving higher drug release. Keywords : METRONIDAZOLE, TOPICAL DELIVERY, IN-VITRO RELEASE, EX-VIVO RELEASE, DIFFUSION BARRIER

Istanbul Medipol University