ACTA Pharmaceutica Sciencia 2020 , Vol 58 , Num 4
Cytotoxic Effect of Some Furanosesquiterpenes from Balsamodendron myrrha Nees. Oleo-gum-Resin on Brine Shrimp (Artemia salina) Larvae Ayesha Asif1,
Ayesha Asif 1 M. Asif Saeed 2
1 Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan
2 Department of Pharmacognosy, University of the Punjab, Lahore, Pakistan
DOI : 10.23893/1307-2080.APS.05824 Furanosesquiterpenes from Balsamodendron myrrha oleo-gum-resin were assessed for their cytotoxic effect. Six Furanosesquiterpenes from hexane insoluble part of EtOH extract of B. myrrha oleoresin was separated, purified by column, preparative TLC and recrystallization. These were identified by comparative spectroscopic data. Cytotoxic effect of these compounds was carried out on brine shrimps" (Artemia salina) larvae (nauplii), evaluated by LD50 after compared with positive controlled colchicine. Six isolated furanosesquiterpenes demonstrated cytotoxic effect against brine shrimps" larvae compared with colchicine. Four sesquiterpenes, compound-1 (myrracadinol-A), compound-2 (myrracadinol-B), compound-5 (furanodiene-6-one) and compound-6 (2-methoxy-furanodiene) was the most active compound compared with compound-3 (furanodiene) and compound-4 (2-acetoxy- furanodiene).From the hexane insoluble part of ethanol extract of B. myrrha oleo-gum-resin, four furanosesquiterpenes were noxious while other two were mild harmful to the brine shrimps" larvae. Keywords : Cytotoxic effect, furanosesquiterpenes, oleo-gum-resin, Balsamodendron myrrha, LD50

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