ACTA Pharmaceutica Sciencia 2004 , Vol 46 , Num 3
SYNERGISTIC EFFECT OF THE COMBINATION TRICLOSAN WITH 2-PHENYLPHENOI AGAINST PSEUDOMONAS AERUGINOSA AND FUNGI
HAİTHAM TUMAH
Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid-, Jordan Triclosan is active against Gram-positive bacteria and against Gram-negative bacteria but less so against Pseudomonas aeruginosa, 2-phenylphenol is considered as effective against fungi, however, its antifungal action is more important than its antibacterial activity. The aim of this study is to evaluate the bactericidal and fungicidal activities of triclosan and 2-phenylphenol alone, and in combination against standard strains of bacteria and fungi. The antibacterial activity of the combination triclosan-2-phenylphenol was significantly enhanced over that of each agent used alone against Pseudomonas aeruginosa. Synergistic effect was also observed against all tested strains of fungi. This combination can be considered to enhance the antimicrobial activity of the two agents. Keywords : TRICLOSAN, 2-PHENYLPHENOL, ANTIBACTERIAL, ANTIFUNGAL

Istanbul Medipol University