ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 1
FLOATING DRUG DELIVERY SYSTEM USING METHOCEL K100M AND E50: FORMULATION AND CHARACTERIZATION
PRAVEEN NASA, SHEEFALİ MAHANT
M.M. College of Pharmacy, M.M. University, Mullana- Ambala, 133203, Haryana, India The aim of the present study was to formulate and characterize a floating drug delivery system, using Methocel K100M and E50. Metformin hydrochloride (Biopharmaceutics Classification System class III) was used as the model drug for the investigation. Effervescent floating tablets of metformin hydrochloride were prepared, employing two different grades of Methocel K100M and E50, by wet granulation method. The two grades were evaluated for their gel forming properties. The floating tablets were evaluated for pre-compression properties as well as in vitro drug release. The prepared tablets exhibited satisfactory precompression characteristics. The data obtained from the study was fitted in different models viz. zero order, first order, Korsmeyer-Peppas model, Higuchi model and Hixon Crowell model. The drug was found to be released by a combination of diffusion and erosion. The slope from Korsmeyer-Peppas model revealed that the drug release followed non-Fickian-type transport mechanism. It was concluded that the formulation F5 (containing 160 mg of Methocel K100M and 40 mg of Methocel E50) was the optimum formulation amongst all the test batches. It may also be concluded from the investigation that a combination of Methocel K100M and Methocel E50 in the ratio of 4:1 may be satisfactorily employed in the formulation of a floating drug delivery system. Keywords : GASTRORETENTIVE, IN VITRO BUOYANCY, HPMC, HYDRODYNAMICALLY BALANCED SYSTEM

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