ACTA Pharmaceutica Sciencia 2009 , Vol 51 , Num 2
FORMULATION AND EVALUATION OF INSULIN ENTERIC MICROSPHERES FOR ORAL DRUG DELIVERY
SANTOSH KUMAR JİNDAL, MALKEET SİNGH, MANİSH GOSWAMİ
Akal College of Pharmacy and Technical Education, Mastuana, Sangrur - 148001 (Punjab) INDIA The goal of the present study was to formulate oral drug delivery device for insulin and to protect the sensitive drug from digestive enzymes and proteolytic degradation in stomach and upper part of gastro intestinal tract (GIT). So, for this purpose insulin enteric microspheres (EMS) were prepared using Hydroxy propyl methyl cellulose acetate succinate as enteric polymer, Bacitracin as protease inhibitor and Sodium oleate as absorption enhancer. In-vitro drug release studies determined that almost no drug was released in HCl (pH 1.2) for 2 hours and then maximum amount of drug was released within 70 minutes in Phosphate buffer (pH 7.4). In-vivo studies on male wistar rats confirmed a remarkable decrease in blood glucose level after 2 hours of administration of insulin EMS. Keywords : INSULIN, INSULIN ORAL DRUG DELIVERY, HYDROXY PROPYL METHYL CELLULOSE ACETATE SUCCINATE, ENTERIC MICROSPHERES, PROTEASE INHIBITOR, ABSORPTION ENHANCER

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