ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 4
DEVELOPMENT AND CHARACTERIZATION OF FLOATING ALGINATE BEADS FOR GASTRORETENTIVE DRUG DELIVERY SYSTEM
KOVİDENDRA KAUSHİK, DEEPTİ CHAURASİA, HİMANSHU CHAURASİA, SANTOSH KUMAR MİSHRA, PEEYUSH BHARDWAJ
Adarsh Vijendra Institute of Pharmaceutical Science, Gangoh, Saharanpur, UP, Pin, India The main object of this study was to involve in development and characterization of novel floating alginate beads of Ranitidine HCl having an air compartment in itself to increase its residence time in the stomach without contact with mucosa. Such floating alginate beads were prepared by Ion-gelation method, using various ratio of CaCl2 as a crosslinking agent in ion gelation media. The presence of air compartment was observed in formulation FF1, FF2 and CFF3, CFF6 by visual examination but only FF1 and CFF3 were found to be buoyant. Average particle size of the formulation FF1 and CFF3 were found to be 1.36± 0.28 mm and 1.45±0.21 mm respectively. Surface morphology of formulations FF1 and CFF3 before and after complete dissolution test were studied by Scanning electron microscopy (SEM). In-vitro drug release studies of selected formulations were performed in 900 ml simulated gastric fluid (1.2 pH) without pepsin. Different drug release kinetics models were also applied for selected batches. Keywords : FLOATING ALGINATE BEADS, CHITOSAN, CALCIUM CHLORIDE (CACL2), RANITIDINE HCL

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