| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 2
Preparation and evaluation of sodium alginate hydrogel sheet loaded with Carica papaya L. seed extract for wound healing
1 LR Institute of Pharmacy, Department of Pharmaceutics, Solan, India2 ICFAI University, Faculty of Pharmaceutical Sciences, Baddi, India
DOI : 10.23893/1307-2080.APS6317 Viewed : 3583 - Downloaded : 2283 In this study, an innovation in the form of a hydrogel sheet containing Carica papaya seed extract was developed and assessed for wound healing activity. The hydrogel sheet was prepared by using sodium alginate, guar gum, glycerol, methyl, and propyl paraben as excipients. Ninehydrogel formulations were prepared by varying the amount of sodium alginate (1.5%, 2.5%, and 3.5%), extract (8%, 10%, and 12%), and guar gum (0.8%, 1.2%, and 1.5%). The formulations prepared were evaluated for physicochemical characteristics like colour, pH, weight variations, folding endurance, tensile strength. Surface characteristics were studied by scanning electron microscopy. Wound healing potential was studied on wistar rats with hydrogel sheet (12%) showing 97.5% wound closure. All hydrogels containing seed extracts showed superior healing performance vis-a-vis control hydrogel. It can be deduced from the in vivo evaluation that the Carica papaya seed extract hydrogel sheet has wound healing properties comparable to the marketed hydrogel sheet. Keywords : sodium alginate, innovation, Carica papaya extract, hydrogel, wound healing