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3 weeks |
|---|---|
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| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 3
Naproxen-phospholipid complex, a new vesicular drug delivery system: Design, development, and evaluation
1 Baghdad College of Medical Sciences, Department of Pharmacy, Baghdad, Iraq2 Kut University College, Department of Pharmacy, Alkut, Wasit, Iraq
DOI : 10.23893/1307-2080.APS6245 Viewed : 4166 - Downloaded : 1419 This study was aimed at preparing and assessing the Naproxen-phospholipid complex (NP-PL) as a vesicular drug delivery system prepared by solvent evaporation method. Attenuated total reflection (ATR) spectroscopy was used to confirm the interaction, while a dissolution study was used to compare the dissolution profiles for the NP drug, the NP-PL complex, and the marketed NP suspension. Results revealed that the ATR spectra showed some changes that confirm the complexation between the PL and NP, and better dissolution behavior was shown by the NP-PL pharmacosomes compared to the NP suspension and the pure NP, which indicates that the potential of making a phospholipid complex with an improved dissolution profile of Naproxen was investigated and a successful NP-PL pharmacosomes was prepared. ATR data confirmed NP-PL complex formation. In-vitro dissolution profiles of NP pharmacosomal dispersion showed improvement over marketed NP and pure NP. Keywords : naproxen, naproxen-phospholipid complex, phospholipid, solvent evaporation method