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ACTA Pharmaceutica Sciencia
2006 , Vol 48 , Num 2
CHLOROQUINE ACCENTUATES ACCELERATED SKIN WOUND HEALING AND REPAIRS IN RAT
Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Nigeria
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The effect of chloroquine an antimalarial drug on full thickness skin wound healing and repairs was studied in rat. Chloroquine and test drugs were ad ministered for 3 days to rat inflicted with cutaneous skin wound. At Day 5, the indices of healing and repairs:- zinc wound tissue content epithelial healing index, skin tension test and dermal proliferative index were evaluated. Chloroquine increased significantly these indices of wound healing compared with control (normal saline treated) and these effects of chloroquine were quantitatively higher compared with Ascorbic acid and chloroquine + tyrphostin treated wounds. Chloroquine administration accelerated wound healing and repair probably due to its effect in inhibiting lysosomal peptidases which are known to degrade the peptide growth factors (with intrinsic tyrosine kinase activity) and collagens necessary for wound repairs.
Keywords :
CHLOROQUINE, ENHANCED SKIN WOUND HEALING AND REPAIRS, RAT