| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 1
COMPARATIVE EVALUATION OF NATURAL AND SYNTHETIC SUPERDISINTEGRANTS WITH NEWER SUPERDISINTEGRANT KYRON T-314
G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, Andhra Pradesh, India
Viewed :
20683
-
Downloaded :
7177
The main objective of this study was to formulate and evaluate the orodispersible tablets of ondansetron hydrochloride with synthetic and natural superdisintegrants. Various formulations were prepared by direct compression using different concentrations of natural superdisintegrant i.e. isolated mucilage of Plantago ovata and synthetic superdisintegrants namely Kyron T-314, crospovidone, and croscarmellose sodium ranging from 0.4% to 2%. The initial compatibility studies between the drug and excipients were carried out using FTIR spectroscopy. The blend was evaluated for additive properties. The tablets were evaluated for physical parameters and in vitro drug release. The disintegration time and in vitro drug release of optimized formulation (FK5) was compared with that of marketed formulation. The disintegration time was found to be 32 sec as compared to 49 sec for marketed formulation. The dissimilarity (f1) and similarity factors (f2) were calculated for optimized and marketed formulation and values were found to be 9.63 and 52.46, respectively. The optimized formulation was subjected to stability studies for three months. The formulation was found to be stable, with insignificant change in the hardness, disintegration time, drug content and in vitro drug release pattern.
Keywords :
ORODISPERSIBLE TABLET, ONDANSETRON HYDROCHLORIDE, KYRON T-314, CROSPOVIDONE, CROSCARMELLOSE SODIUM, ISOLATED MUCILAGE OF PLANTAGO OVATA