| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2023 , Vol 61 , Num 1
Development of Mefenamic Acid-Soluplus ® amorphous dispersions via hot melt extrusion and in silico prediction of oral absorption
1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, IndiaDOI : 10.23893/1307-2080.APS6101 Viewed : 9228 - Downloaded : 3749 The objective of this study was to increase the solubility of Mefenamic Acid (MA), a BCS class II drug by formulating amorphous solid dispersions via Holt-Melt Extrusion. The extrudates were prepared at different drug to polymer ratios and characterised by standard analytical techniques. Dissolution studies were performed in Phosphate buffer saline (PBS) pH 7.4 medium. Stability of the different ratios of MA: Soluplus (1:1, 1:4 and 4:1) was studied at room temperature for 12 months. Computer simulation using GastroPlusTM was run to depict the gastrointestinal absorption of MA in humans. DSC thermograms and the diffractograms of the solid dispersions confirmed amorphous nature. Dissolution studies showed enhanced dissolution rate of MA from the solid dispersions. Stability studies indicated 1:4 (MA: Soluplus®) dispersion as the most stable dispersion. GastroPlus? simulation using in vitro data showed improvement in the PK parameters of the solid dispersión in comparison with pure MA. Keywords : Hot-melt extrusion, Metanamic Acid, Soluplus, solubilisation, solid dispersion