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ACTA Pharmaceutica Sciencia 2022 , Vol 60 , Num 2
In vitro ACE2 Enzyme Inhibitory Activity Evaluation of Different Salvia Essential Oils
Ayse Esra KARADAĞ 1-2 Sevde Nur BILTEKIN 3-4 Betül DEMIRCI 5 Fatih DEMIRCI 5-6
1 Department of Pharmacognosy, School of Pharmacy, Istanbul Medipol University, 34810, Istanbul, TURKEY
2 Depatment of Pharmacognosy, Graduate School of Health Sciences, Anadolu University, Eskişehir , TURKEY
3 Department of Pharmaceutical Microbiology, School of Pharmacy, Istanbul Medipol University, 34810-Beykoz, Istanbul, Turkey
4 Institute of Sciences, Istanbul University, 34116-Istanbul, Turkey
5 Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470-Eskişehir, Turkey
6 Faculty of Pharmacy, Eastern Mediterranean University, 99450-Famagusta, N. Cyprus, Mersin 10, Turkey
DOI : 10.23893/1307-2080.APS.6008 In this present study, commertially available Salvia triloba L., S.officinalis L., and S. sclarea L. essential oils were evaluated for their in vitro angiotensin converting enzyme 2 (ACE2) inhibitory activity. The Salvia essential oils compositions were confirmed both by GC-FID and GC/MS. Main components of the S. triloba essential oil was characterized as 1,8-cineole (22.8%), camphor (17.2%), ?-thujone (15.2 %), ?-caryophyllene (11.4 %), and ?-humulene (3%). Major constiutents were identified as ?-thujone (28.5 %), camphor (20.6 %), 1,8-cineole (10.9%), ?-humulene (5%), and camphene (4.9 %) in S. officinalis essential oil. Whereas, linalylacetate (56.8 %), linalool (21.1%), ?-terpineol (6.1%), geraniol (5%), and ?-caryophyllene (3.4%) were the major components of S. sclarea essential oil. The essential oils were evaluated using a fluorometric multiplate based enzyme inhibition kit, where the ACE2 inhibitions of S. triloba, S. officinalis, and S. sclarea essential oils were 50.1%, 60.5%, and 72.1% at a concentration of 20 µg/mL, respectively. As a result, further tests of Salvia essential oils supported by in vivo studies may have antiviral potential applications against coronaviruses due to ACE2 enzyme inhibitions. Keywords : Salvia, coronavirus, ACE2, essential oil

Istanbul Medipol University