| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2022 , Vol 60 , Num 1
Anticancer potentials of Morinda lucida and Annona muricata on Ki67 and Multidrug resistance1 genes expressions in Sodium arsenite-induced hepato-toxicity in rats
1 Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences Ondo, Ondo State, Nigeria2 Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria
3 Department of Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria
4 Department of Biochemistry, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State, Nigeria
DOI : 10.23893/1307-2080.APS.6005 Viewed : 16544 - Downloaded : 4503 This study evaluated anticancer potentials of Morinda lucida (ML) and Annona muricata (AM) on Ki67 and Multi-drug resistance1 (MDR1) concentrations in livers of rats in Sodium arsenite (SA)-induced hepato-toxicity. 60 adult female rats were randomly divided into 12 groups (n= 5). Groups 1 and 2 received physiological saline and 10mg/kg bodyweight of SA respectively. Groups 3-6 received SA followed by treatments with ML and AM doses. Groups 7-10 received extracts only. Groups 11-12 received co-administrations of SA with extracts. Drugs/extracts were administered orally. Experimental procedure was 5 weeks. Consequently, Liver histo-pathology and ELISA concentrations of Ki67 and MDR1 were evaluated. Data were statistically analyzed (P?0.05). Results showed decreased levels of Ki67 (Groups 11-12) and MDR1 (Groups 3-4 and 11) compared with Group 2, indicating that ML ameliorated SA-induced hyperplasia and drug resistance, while AM ameliorated SA-induced hyperplasia. Therefore, ML possesses anti-proliferation and anti-drug resistance potentials, while AM possesses anti-proliferation potentials. Keywords : Morinda lucida, Annona muricata, Sodium arsenite, Ki67 and Multidrug resistance1