ACTA Pharmaceutica Sciencia Accepted Manuscripts
Phytochemical profiling and antioxidant activities of Monodora myristica and Dennettia tripetala against lipid peroxidation in rat heart
Kayode Olayele KARIGIDI 1 Emmanuel Sina AKINTIMEHIN 1 Damilola Alex OMOBOYOWA 2 Foluso Olutope ADETUYI 1
1 Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo state
2 Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko, Ondo state
This study was carried out to investigate the phytochemical profiling and in vitro antioxidant activities of methanol extract of Monodora myristica (MM) and Dennettia tripetala (DT) against lipid peroxidation in rat"s heart. The antioxidant activities and lipid peroxidation inhibition were evaluated with spectrophotometric methods. Thereafter, the extracts were profiled using high performance liquid chromatography (HPLC) method. The results showed that MM and DT possessed polyphenol content which culminated in antioxidant activities. However, MM exhibited significantly higher (p < 0.05) antioxidant activities than DT. Also both extracts were able to inhibit lipid peroxidation in rat"s heart in vitro. The extracts profiling showed the abundance presence of myristyl chloride, linalool and nerolidal in MM extract and elemicin, myristicin, eugenol and pinene in DT extract. Therefore, it can be concluded that MM and DT may be used against oxidant related diseases of the heart. Also, there might be need to isolate these compounds and evaluate them for probable drug lead Keywords : Antioxidant, Dennettia tripetala, Lipid peroxidation, Monodora myristica, HPLC

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