| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
2 Ondokuz Mayıs University, Faculty of Science and Literature, Department of Chemistry
DOI : 10.23893/1307-2080.APS.05918 Viewed : 20102 - Downloaded : 5616 Nanosponges (NSs) are non-toxic, porous, solid polymers, having three dimensional structures which stable at high temperature and can form inclusion complexes with many molecules due to their cavity size. NSs are prepared by reacting β-cyclodextrin (β-CD) with cross-linkers such as pyromellitic anhydride, hexamethylene diisocyanate, carbonyl-diimidazole or diphenyl carbonate.
Many anti-cancer drugs with both hydrophilic and lipophilic properties can be loaded or integrated into NS and ultimately increase the characteristics of the drugs. The most important properties and advantages of NSs are easily synthesized and modified, provide high drug loading capacity along with controlled release, increase the solubility and bioavailability of water-soluble molecules. In addition, NSs protect the degradable actives from environmental influences, biologically safe and biodegradable compared to other nanocarriers. This review has highlighted the structure and properties of CD-NS as well as demonstrating a new generation of functionalized NS studies as an innovative drug delivery agent for pharmaceutical applications.
Keywords : Nanosponge, Cyclodextrin, Nanocarriers, Controlled Drug Delivery, Guided Drug Delivery, Cancer