| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2021 , Vol 59 , Num 1
Protective Effect of Exendin-4 Treatment On Oxidative Status Of Liver In Rats Exposed To Chronic Methylglyoxal
1 Akdeniz University, Medical Faculty, Department of Medical Pharmacology, 07070, Antalya, Turkey2 Akdeniz University, Medical Faculty, Department of Medical Biochemistry, 07070, Antalya, Turkey
DOI : 10.23893/1307-2080.APS.05910 Viewed : 17596 - Downloaded : 5317 The protective effects of Glucagon-Like Peptide-1 (GLP-1) agonists against oxidative stress-induced cellular injury have been well established by previous experimental and clinical studies. Male Wistar rats (200-250 g weight, n=24) were used in this study. First group of rats were not treated with Methylglyoxal (MGO) and served as control group (C group). Second group of rats (MGO group) received MGO (75 mg/ kg/day in drinking water) for 12 weeks. Third group of rats (MGO+Ex-4) received Exendin-4 (Ex-4) (1 µg/kg twice daily subcutaneously) concomitant with MGO for 12 weeks. At the end of the 12th week, total oxidant status (TOS), total antioxidant capacity (TAC), sulfhydryl groups (SH), myeloperoxidase (MPO), and advanced oxidation protein products (AOPP) in the liver tissues of all groups were measured spectrophotometrically. In MGO-administered rats, TOS, MPO and AOPP levels were significantly increased. Treatment with Ex-4 for 12 weeks caused a significant decline in the levels of these markers in rats exposed to MGO. Also, levels of TAC and SH were decreased significantly after the 12 weeks of MGO administration. 12 weeks treatment with Ex-4 also increased the levels of TAC and SH in liver tissues of MGO-administered rats. Ex-4 treatment improves oxidative parameters of liver tissue in MGO-administered rats by improving oxidant-antioxidant balance. Keywords : Exendin-4, Methylglyoxal, Oxidative stress, Live