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ACTA Pharmaceutica Sciencia 2019 , Vol 57 , Num 4
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Design and Characterization of the Material Attributes of a Co-processed Excipient Developed for Direct Compression Tableting
Yonni Apeji 1-2 Fatima Haruna 2 Avosuahi Oyi 2 Adamu Isah 2 Teryila Allagh 2
1 National Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmaceutics, Sector 67, S.A.S Nagar, Punjab 160 062, India
2 Ahmadu Bello University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Industrial Pharmacy, Zaria, Kaduna State, Nigeria
DOI : 10.23893/1307-2080.APS.05723 Viewed : 18221 - Downloaded : 6512 The objective of the study was to characterize the material attributes of a co-processed excipient and determine its suitability for tableting applications.

A single composite excipient named SGS consisting of tapioca starch (TS), gelatin (GEL) and colloidal silicon dioxide (CSD) was developed by co-processing using the method of co-fusion and its solid-state, powder and mechanical properties evaluated.

Particle morphology revealed spherical shaped particles of SGS with slightly rough surfaces. PXRD was characterized by a halo diffraction pattern consistent with amorphous materials. FT-IR studies demonstrated drug-excipient compatibility. Flow properties of SGS improved in relation to its physical mixture (SGS-PM) and the mechanical properties of SGS was enhanced as a result of co-processing. The outcome of the study demonstrates the suitability of SGS as a tableting excipient. Keywords : Material attributes, starch, co-processed excipient, tableting

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