| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2018 , Vol 56 , Num 3
Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel Isoxazoline Derivatives
1 Mustansiriyah University, Department of Chemistry, Baghdad, IraqDOI : 10.23893/1307-2080.APS.05619 Viewed : 19211 - Downloaded : 6729 A novel series of isoxazoline derivatives (3-10) was synthesized and characterized by using spectral analysis. The synthesized derivatives were in vitro screened against several bacterial species as well as Candida albicans and exhibit moderate to potent activity. All the synthesized products were screened qualitatively for their antioxidant property by using TLC technique and the percent DPPH radical scavenging activity of the potent derivatives (4-6,8) were evaluated. Docking study of isoxazoline derivatives 7 and 8 against L-Glutamine: D-fructose-6-phosphate amidotransferase (glucosamine-6-phosphate synthase), the target enzyme in antimicrobial chemotherapy, was evaluated to explore the interactions of the synthesized hits inside the amino acid residues of the enzyme active site. The docking outcomes strongly supported the in vitro assay of new derivatives against several microbial species. Keywords : Isoxazoline, antimicrobial, antioxidant, docking study