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3 weeks |
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ACTA Pharmaceutica Sciencia
2018 , Vol 56 , Num 3
Beta Hematin Inhibition: Evaluating the Mechanism of Action of Some Selected Antimalarial Plants
1 University of Ibadan, Department of Pharmacology & Therapeutics, Ibadan, NigeriaDOI : 10.23893/1307-2080.APS.05618 Viewed : 18588 - Downloaded : 5785 There is paucity of information regarding the mechanism of action of medicinal plants with antimalarial activity. Thus, the mechanism of action of twenty antimalarial plants using the ?-hematin inhibition assay was evaluated. Beta-hematin synthesis from bovine hemin in the presence of saturated acetate solution at a temperature of 60°C and pH 7.5 was initiated with a fixed concentration of 0.69 mg/ mL of chloroquine or methanol extracts of the selected plants. The fifty percent inhibitory concentration (IC50) of the six most active plant extracts/standard drug was determined using linear regression. Two of the plant extracts A. boonei and M. charantia (IC50 = 0.09 ± 0.03 and 0.11 ± 0.02 mg/mL), showed significant activity than chloroquine (0.36 ± 0.16 mg/ml. P<0.05) a potent ?-hematin inhibitor. The ?-haematin colorimetric assay is a reliable assay for determining the mechanism of action of medicinal plants that utilize the pathway. Keywords : Beta haematin, antimalarial plants, Nigerian ethnomedicine