Acceptance rate 46%
Time to first decision 5 days*
Time to decision with review 50 days*

*approximate number of days


ACTA Pharmaceutica Sciencia 2004 , Vol 46 , Num 2
ANTIDIARRHOEAL ACTHRITY OF ARGYREIA SPECIOSA FLOWER: AN ETHNOPHARMACOLOGICAL STUDY
V RAO, S K OJHA, G D REDDY, A K S RAWAT, G M M RAO, P PUSHPANGADAN
Ethnopharmacology Division, National Botanical Research Institute, (Council of Scientific and Industrial Research) Rana Pratap Marg, Uttar Pradesh, INDIA Diarrhoea is a wide spread disease that is often reported to the physicians for treatment, in additioll to countless instances where diarrhoea is treated by folklore medicine. Argyreia speciosa Sweet (Convulvulaceae) commonly known as Elephant creepr. The 50% ethanolic flower extract of A. speciosa was undertaken to evaluate the anti-diarrhoeal activity against validated experimental models of diarrhoea in rats. The flower extract has standardis'ed by HPTLC analysis in the Toluene: Ethylacetate: Formic acid (5: 5: I) and resolved peaks were visualised at 336nm with a 400 k filter at 0.52, 0.60, 0.70 and 0.77 Rf. The λ max for major spots was 332, 320, 288 and 291 respectively. The densitometric absorption at 200nm was 31.29%, 27.79%, 22.06% and 14.89%. Administration of extract 50- 150 mgkg -1 orally showed dose dependent decrease in the intestinal propulsion from 6 1.54% - 41.36%, which is equivalent to 38.46% - 58.64% intestinal propulsive inhibition relative to control 27.23%. Further study on castor oil induced diarrhoea and intestinal fluid accumulation causes a dose dependent decrease in the number of faecal matter and a significant reduction in the intestinal fluid accumulation from 9.97% -39.58%. The results suggest that flower extract of A. speciosa had sig,nificant antidiarrhoeal activity. Keywords : ARGYREIA SPECIOSA SWEET, DIARRHOEA, FLOWERS

Istanbul Medipol University