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ACTA Pharmaceutica Sciencia
2004 , Vol 46 , Num 1
STUDIES ON ELEMENTARY OSMOTIC PUMP TABLETS OF NAPROXEN SODIUM
Department of Pharmaceutics, IT, Banaras Hindu University, Varanasi , INDIA
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The present investigation embodies the development of elementary osmotic pump tablets(OPT) of Naproxen sodium (NS) for per-oral administration mainly with an objective to deliver a constant, predetermined amOtillt of drug in solution form for extended duration. Core tablets of OPT were prepared by compression using drug, different osmegens, microcrystalline cellulose (MCC), PVP and optional excipients like sodium lauryl sulphate(SLS) and sodium bicarbonate (SBC) on tabletting machine. Core tablets were coated using 2% w/v cellulose acetate dissolved in IPA:acetone (1: 9) mxture. All the OPT were evaluated for physical parameters and in vitro dmg release characteristics in sequenced gastrointestinal(Gl) fluid. The observation of drug release from OPT indicated controlled and prolonged release of NS in comparison to standard marketed formulation of NS. The rate and extent of drug release from OPT were found to be dependent on the presence of different osmogens, SLS and SEC in the core and independent on agitation intensity of the release medium.
Keywords :
NAPROXEN SODIUM, ELEMENTARY OSMOTIC PUMP, OSMOTIC PUMP TABLET, CELLULOSE ACETATE