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ACTA Pharmaceutica Sciencia
2004 , Vol 46 , Num 1
IN VITRO CHARACTERIZATION OF PHYSICALLY REINFORCED OCULAR INSERTS OF INDOMETHACIN
Departnlent of Pharmaceutics, Institute of Technology Banaras Hindu University Varanasi - INDIA
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Physical reinforcelnents of polyvinyl alcohol (PVA; high - 125,000 and low- 14,000 moleculer weights) based ocular inserts of indonlethacin were conducted by subjecting to heat (80° C and 100° C for 24 and 48 hours) and freeze-thaw cycles (3 and 6 cycles). In vitro drug release was studied in a continous flow through apparatus and compared with the nonreinforced inserts. The rate of indomethacin release was inversely proportional to the content of low molecular weight PV A (PVA 14,000). The duration of heating had more effect on release properties than tile tempature and the release pattern of freeze thawed inserts showed lower drug release than the non-reinforced and heat treated inserts.
Keywords :
OCULAR INSERTS, INDOLNETHACIN, HEATING AND FREEZE-THAWING