| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2009 , Vol 51 , Num 2
SHIFTING PRODUCTION OF RIFAMYCIN-SV BY MUTANT OF AMYCOLATOPSIS MEDITERRANEI TOLERANT TO BENZYL ALCOHOL
National Research Center, Che. of Natural and Microbial Products Dept., Dokki-Cairo-EGYPT
Viewed :
20875
-
Downloaded :
6269
Benzyl alcohol is a toxic hydrophobic compound for the microorganisms but using at specific concentration, 0.25%, a mutant of A. mediterranei-CBS-42575 was selected which has the maximum metabolism shifting of rifamycin-B from 1460 into 95(mg l-1) into rifamycin-SV upto 4.896 (g l-1). At the optimum fermentation differentiation between A. mediterranei-CBS- 42575 and its benzyl alcohol mutant in kinetic analysis was established, the resulted values for the growth yield coefficient YX/S was decreased from 0.4663 for the parent strain into 0.311 and 0.3675 (g cells g glucose-1 l-1) for the mutant in the shake flasks and the fermentor respectively. Also Monod growth saturation coefficient (Ks) recorded values, 1.01 for the parent strain while 0.95 and 1.57 (g S l-1) for the mutant in the shake flasks and the fermentor respectively. Also, YP/X was 0.373 for the parent strain and increased upto 1.0756 and 0.98 (g rif.-SV g cells-1) for the mutant in the shake flasks and the fermentor respectively. Also, the maximum of yield coefficients of refamycin-SV, YP/S, were obtained, 0.2523 and 0.3144 (g rif.-SV g glucose-1) for the mutant in the shake flasks and fermentor respectively.
Keywords :
RIFAMYCIN-SV, AMYCOLATOPSIS MEDITERRANEI, BENZYL ALCOHOL, HYDROPHOBIC COMPOUNDS, FERMENTATION, KINETIC ANALYSES