| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 1
TOXICITY ASSESSMENT OF A Β-GALACTOSIDE-BINDING LECTIN (GALECTIN-1) FROM BULLFROG RANA CATESBEIANA UNFERTILIZED EGGS
1Laboratory of Glycobiology and Marine Biochemistry, Department of Genome System Science, Graduate School of Nano Biosciences, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama
Viewed :
18617
-
Downloaded :
6131
The present study was undertaken to investigate the toxicity of β-galactoside-binding lectin (galectin-1) using the brine shrimp lethality bioassay technique. Galectin-1 was purified from the American bullfrog Rana catesbeiana unfertilized eggs by conventional affinity chromatography method. The molecular mass of the galectin-1 was determined to be 15 kDa by SDS-PAGE under non-reducing and reducing conditions, respectively. Galectin-1 affects significantly the mortality rate (56.66%) of brine shrimp (Artemia salina L.) lethality bioassay. The results exhibited that galectin-1 was found to be moderate toxic and the mortality rate of brine shrimp nauplii was increased with the increase in concentration of galectin- 1. These findings suggest that the galectin-1 obtained from amphibian may have anticancer and antitumor activity and would be useful to clinical microbiology to play a significant role in human therapy.
Keywords :
GALECTIN-1, RANA CATESBEIANA, BRINE SHRIMP, TOXICITY, MORTALITY