| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
EFFECT OF MURRAYA KOENIGII PRETREATMENT ON THE TRANSPORT OF BUSPIRONE ACROSS RAT INTESTINE
Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A.P. India
Viewed :
18899
-
Downloaded :
6071
To investigate the effect of Murraya koenigii fruit (aqueous extract) pretreatment on transport of buspirone, a CYP3A4 substrate across the rat intestine. The transport of buspirone across rat intestine (duodenum, jejunum and ileum) was studied by using non-everted sac method. The rats were pretreated with Murraya koenigii fruit (aqueous extract) for 7 days. The rats were sacrificed by using anesthetic ether, the intestinal segments were isolated and used for the studies. The probe drug (buspirone) solution was placed in the isolated intestinal sac. Samples were collected at preset time points and replaced with fresh buffer. The drug content in the samples was estimated using high performance liquid chromatography method. Control experiments were also performed. The results revealed that there was a significant (p<0.05) difference compared to control, in the transport of buspirone from the intestinal sacs which were pretreated with M. koenigii fruit (aqueous extract). It suggests that both M. koenigii aqueous extract might be acting by inhibiting the transporters and enzymes which are responsible for transport/metabolism of buspirone. From the results it can be concluded that M. koenigii fruit aqueous extract might be acting by inhibiting CYP3A4 enzymes as buspirone is extensively metabolized by CYP3A4. Further studies are recommended to prove their effects in human beings.
Keywords :
CYTOCHROME P-450 3A, NONEVERTED SAC, MURRAYA KONEGII