ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 2
PREPARATION AND EVALUATION OF TERBUTALINE SULPHATE MICROSPHERES USING FACTORIAL DESIGN
RAJENDRA KOTADİYA, VİSHNU PATEL, HARSHA PATEL, BHAVRAM SALANİYA
Indukaka Ipcowala College of Pharmacy, New V V Nagar, Gujarat, India The aim of this study was to formulate and evaluate microspheres of terbutaline sulphate (TBS) by waterin- oil-in-water emulsion solvent diffusion method using ethyl cellulose. The influence of drug content (X1) and polymer content (X2) on physicochemical properties of the microspheres viz. Encapsulation efficiency (EE) and time for 70% drug dissolution (t70) was investigated by using 32 factorial design. The microspheres were smooth, spherical in shape and free flowing with particle size ranges from 18 μm to 27 μm. The results of multiple linear regression analysis revealed that for obtaining controlled drug release with high EE, the microspheres should be prepared using relatively lower levels of drug and higher levels of polymer. Keywords : FACTORIAL DESIGN, ENCAPSULATION EFFICIENCY, T70, SURFACE PLOT

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