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ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
DEVELOPMENT AND CHARACTERIZATION OF GLIPIZIDE LOADED TRANSDERMAL MATRIX PATCHES WITH PENETRATION ENHANCERS
School of Pharmaceutics, Shobhit University. Merrut (UP), India
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We aimed to develop matrix type transdermal delivery system of glipizide for its delivery via skin using penetration enhancers. Glipizide loaded transdermal matrix system containing different amounts of ethyl cellulose (EC) and polyvinylpyrrolidone K-30 (PVP) were prepared by the solvent evaporation technique. The combined effect of oleic acid (OA) and propylene glycol (PG) as penetration enhancers on the percutaneous permeation of drug was studied. The patches containing 5% OA+1% PG exhibited highest release rate and highest drug permeation at the end of 24 h. Moreover, in vivo studies with glipizide showed significant hypoglycemic activity.
Keywords :
TRANSDERMAL PERMEATION, ETHYL CELLULOSE, POLYVINYLPYRROLIDONE K-30, PENETRATION ENHANCERS, HUMAN CADAVER SKIN