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ACTA Pharmaceutica Sciencia
2005 , Vol 47 , Num 2
PROPRANOLOL HYDROCHLORIDE SUSTAINED-RELEASE PELLETS PREPARED WITH LABORATORY SCALE TOP SPRAY FLUID BED SYSTEM
Ege University, Faculty of Pharmacy Pharmaceutical Technology Department, Bornova, Izmir, TURKEY
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The aim of the present study was to prepare propranolol hydrochloride sustained release pellets using a laboratory scale top spray fluid bed system and to evaluate the suitability of the system. Drug-binding agent formulation was sprayed onto nonpareils, then drug loaded pellets obtained were coated with aqueous ethylcellulose dispersion. Coated pellets were evaluated for their particle size and size distribution, bulk and tapped densities, and flowability. Hence the process of laboratory scale top spray fluid bed system was evaluated in respect of suitability to prepare sustained release pellets.
Keywords :
SUSTAINED RELEASE PELLET, COATING, TOP SPRAY FLUID BED, SIMILARITY FACTOR