Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.


ACTA Pharmaceutica Sciencia 2005 , Vol 47 , Num 2
PROPRANOLOL HYDROCHLORIDE SUSTAINED-RELEASE PELLETS PREPARED WITH LABORATORY SCALE TOP SPRAY FLUID BED SYSTEM
MESUT ARİCİ, TAMER GÜNERİ
Ege University, Faculty of Pharmacy Pharmaceutical Technology Department, Bornova, Izmir, TURKEY The aim of the present study was to prepare propranolol hydrochloride sustained release pellets using a laboratory scale top spray fluid bed system and to evaluate the suitability of the system. Drug-binding agent formulation was sprayed onto nonpareils, then drug loaded pellets obtained were coated with aqueous ethylcellulose dispersion. Coated pellets were evaluated for their particle size and size distribution, bulk and tapped densities, and flowability. Hence the process of laboratory scale top spray fluid bed system was evaluated in respect of suitability to prepare sustained release pellets. Keywords : SUSTAINED RELEASE PELLET, COATING, TOP SPRAY FLUID BED, SIMILARITY FACTOR

Istanbul Medipol University