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ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
PREPARATION AND CHARACTERIZATION OF POLY(ACRYLIC ACID-CO-METHYL METHACRYLATE) MICROPARTICLES AS SUSTAINED DRUG DELIVERY SYSTEM OF ANTIHYPERTENSIVE DRUGS
Department of Pharmaceutics, JSS College of Pharmacy, JSS University, SS Nagar, Mysore, Karnataka, India
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The objective of the present study was to develop a sustained drug delivery system for highly watersoluble (diltiazem hydrochloride and metoprolol tartrate) drugs using pH sensitive monomers (acrylic acid and methyl methacrylate). The monomers were polymerized using ammonium persulphate as initiator. The polymers were then cross-linked with ethyleneglycol dimethacrylate as crosslinking agent. The prepared microparticles were characterized by FT-IR and DSC for drug and polymer compatibility and surface morphology of the particles was studied by SEM. FT-IR and DSC studies showed no chemical interaction between the drug and polymers. The release of drug followed Non Fickian diffusion type.
Keywords :
DILTIAZEM HYDROCHLORIDE, METOPROLOL TARTRATE, ACRYLIC ACID, METHYL METHACRYLATE, ETHYLENEGLYCOL DIMETHACRYLATE