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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 1
CHITOSAN ACETATE BASED IN-SITU SOLID DISPERSIONS OF CARBAMAZEPINE
Biopharmaceutical Research Group, Department of Biopharmaceutics, Govt. College of Pharmacy, Karad, Maharashtra, India
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Chitosan is a polysaccharide comprising of co-polymers of glucosamine and N-acetyl glucosamine and is widely used in drug delivery applications such as dissolution enhancer, permeation enhancer, bioadhesive polymer, matrix former etc. Chitosan acetate based solid dispersions and physical mixtures were prepared to improve the biopharmaceutic characteristics of carbamazepine. The prepared formulations were characterized for its chemical compatibility (FTIR), thermal behavior (DSC), crystallinity (PXRD) and in vitro drug dissolution testing. The in vitro drug dissolution studies of physical mixtures and solid dispersions revealed that the dissolution enhancement of carbamazepine in chitosan acetate carrier. The maximum release of 90.81 % was achieved with solid dispersion formulation containing 70% of chitosan acetate. The drug release was independent of polymer concentration in formulation. Further studies required exploring the effect of processing technique on dissolution profile of formulations. The research finding concludes that chitosan acetate can be used as carrier for delivery of poor soluble drug such as a carbamazepine.
Keywords :
CARBAMAZEPINE, CHITOSAN, CHITOSAN ACETATE, SOLID DISPERSIONS, DISSOLUTION