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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 1
PROTECTIVE EFFECT OF CURCUMIN AGAINST THE GENOTOXIC DAMAGE INDUCED BY TINIDAZOLE IN CULTURED HUMAN LYMPHOCYTES
Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh
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Tinidazole (TNZ) is used in the treatment of trichomoniasis, giardiasis and amebiasis. It has been reported as cytotoxic and genotoxic agent in various in vitro and in vivo models. Natural plant products having antioxidant properties can reduce the genotoxic effects of the drugs, if give in combination and thereby reduced the chances of developing cancer during the prolonged treatment with certain drugs. In the present study the effect of 5, 10 and 15 μM of curcumin was studied against the genotoxic doses of tinidazole i.e. 10 and 20 μg/ml, using lipid peroxidation, micronucleus and sister chromatid exchange as a parameters on cultured human lymphocytes. A significant dose dependent decrease in the genotoxic effects of TNZ was observed suggesting a protective role of curcumin against the drug.
Keywords :
TINIDAZOLE, LIPID PEROXIDATION, MICRONUCLEUS, SISTER CHROMATID EXCHANGE, CURCUMIN