ACTA Pharmaceutica Sciencia 2007 , Vol 49 , Num 2
PHARMACOKINETIC VARIATIONS OF SULFAFURAZOLE IN 'FAST' AND 'SLOW' ACETYLATORS
V P PANDEY, J K PANDİT
Department of Pharmaceutics, I.T, B.H.U., Varanasi - India A number of therapeutically important drugs are reported to show the phenomena of fast and slow acetylation. The bimodal Acetylation of sulfafurazole has not yet been reported, although there is a distinct possibility. Individual sulfonamides differ in the extent they are absorbed in the extent they reach body tissues, and in the rate they are eliminated from the body. The present report describes the phenomena of two acetylator phenotypes for sulfafurazole. Keywords : SULFAFURAZOLE (SULFISOXAZOLE), BIMODAL ACETYLATOR PHENOTYPES

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