| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 3
A novel multi-layer mucoadhesive buccal film containing liposomal Sumatriptan: Development and in vitro drug release kinetics evaluation
1 Lorestan University of Medical Sciences, School of Pharmacy, Khorramabad, Iran2 Lorestan University of Medical Sciences, Razi Herbal Medicines Research Center, Khorramabad, Iran
DOI : 10.23893/1307-2080.APS6333 Viewed : 26 - Downloaded : 11 This study introduces a new three-layered buccal film for the controlled drug delivery of Sumatriptan. Sumatriptan was loaded in cationic liposomes and embedded in a hyaluronic acid film. This film was sandwiched between a mucoadhesive layer of carbopol® 934P/HPMC K4M and an ethylcellulose backing layer. The systems" characteristics were evaluated, including thickness, weight uniformity, swellability, mucoadhesive strength, etc. Also, the in vitro release kinetics of Sumatriptan were assessed using DDSolver software. The nanoliposomes showed a spherical shape with average size, zeta potential, and entrapment efficiency of 138.3 ± 3.99 nm, 17.3 ± 2.7 mv and 75% ± 4.16, respectively. The final system exhibited a suitable mucoadhesive strength (1225 Pascal) by altering the swelling and disintegration of layers, the backing layer facilitated the unilateral drug release toward the mucus, resulting in prolonged drug release. About 90% of Sumatriptan was released within 24 h through predominant diffusion and polymer relaxation mechanisms. Keywords : buccal drug delivery, drug release, liposomal Sumatriptan, mucoadhesive film