| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 3
A novel multi-layer mucoadhesive buccal film containing liposomal Sumatriptan: Development and in vitro drug release kinetics evaluation
1 Lorestan University of Medical Sciences, School of Pharmacy, Khorramabad, Iran2 Lorestan University of Medical Sciences, Razi Herbal Medicines Research Center, Khorramabad, Iran
DOI : 10.23893/1307-2080.APS6333 Viewed : 2442 - Downloaded : 1186 This study introduces a new three-layered buccal film for the controlled drug delivery of Sumatriptan. Sumatriptan was loaded in cationic liposomes and embedded in a hyaluronic acid film. This film was sandwiched between a mucoadhesive layer of carbopol® 934P/HPMC K4M and an ethylcellulose backing layer. The systems" characteristics were evaluated, including thickness, weight uniformity, swellability, mucoadhesive strength, etc. Also, the in vitro release kinetics of Sumatriptan were assessed using DDSolver software. The nanoliposomes showed a spherical shape with average size, zeta potential, and entrapment efficiency of 138.3 ± 3.99 nm, 17.3 ± 2.7 mv and 75% ± 4.16, respectively. The final system exhibited a suitable mucoadhesive strength (1225 Pascal) by altering the swelling and disintegration of layers, the backing layer facilitated the unilateral drug release toward the mucus, resulting in prolonged drug release. About 90% of Sumatriptan was released within 24 h through predominant diffusion and polymer relaxation mechanisms. Keywords : buccal drug delivery, drug release, liposomal Sumatriptan, mucoadhesive film