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ACTA Pharmaceutica Sciencia
2005 , Vol 47 , Num 3
HPLC ANALYSIS OF LISINOPRIL IN TABLETS
Department of Pharmaceutical Chemistry, Faculty of PharmacyDunav str. Sofia, Bulgaria
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HPLC method was applied for the identification of Lisinopril in trade pharmaceutical products - tablets. The HPLC analytical parameters: retention time (tR), capacity factor for the analyte peak (k'), number of theoretical plates (N) and tailing factor for the analyte peak (T), for tablets with different content of Lisinopril: 5 mg, 10 mg, 20 mg were compared. The data for the quantity of drug and for parameters of validation procedure: repeatability (precision) and accuracy for Lisinopril tablets 10 mg, 20 mg and for model mixtures with Lisinopril, were obtained by HPLC method. The results from the analysis of Lisinopril in tablets correspond to the USP XXIV requirements.
Keywords :
ACCURACY, HPLC ANALYSIS, LISINOPRIL, TABLETS, REPEATABILITY