| Acceptance rate | 46% |
|---|---|
| Time to first decision | 20 days* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2022 , Vol 60 , Num 1
Anticancer potentials of Morinda lucida and Annona muricata on Ki67 and Multidrug resistance1 genes expressions in Sodium arsenite-induced hepato-toxicity in rats
1 Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences Ondo, Ondo State, Nigeria2 Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria
3 Department of Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria
4 Department of Biochemistry, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State, Nigeria
DOI : 10.23893/1307-2080.APS.6005 This study evaluated anticancer potentials of Morinda lucida (ML) and Annona muricata (AM) on Ki67 and Multi-drug resistance1 (MDR1) concentrations in livers of rats in Sodium arsenite (SA)-induced hepato-toxicity. 60 adult female rats were randomly divided into 12 groups (n= 5). Groups 1 and 2 received physiological saline and 10mg/kg bodyweight of SA respectively. Groups 3-6 received SA followed by treatments with ML and AM doses. Groups 7-10 received extracts only. Groups 11-12 received co-administrations of SA with extracts. Drugs/extracts were administered orally. Experimental procedure was 5 weeks. Consequently, Liver histo-pathology and ELISA concentrations of Ki67 and MDR1 were evaluated. Data were statistically analyzed (P?0.05). Results showed decreased levels of Ki67 (Groups 11-12) and MDR1 (Groups 3-4 and 11) compared with Group 2, indicating that ML ameliorated SA-induced hyperplasia and drug resistance, while AM ameliorated SA-induced hyperplasia. Therefore, ML possesses anti-proliferation and anti-drug resistance potentials, while AM possesses anti-proliferation potentials. Keywords : Morinda lucida, Annona muricata, Sodium arsenite, Ki67 and Multidrug resistance1