Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.


ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 3
POTENT INHIBITORS OF TYROSINASE ACTIVITY FROM CITRULLUS COLOCYNTHIS SCHRAD. (CUCURBITACEAE)
FADİMATOU, J MOMENİ, S F KİMBU, B L SONDENGAM, MAHMUD TAREQ HASSAN KHAN, M IQBAL CHOUDHARY, ATTA-UR-RAHMAN
Department of Chemistry, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon A new fatty acid glucoside, citrulloside (1) along with nine known compounds were isolated from the fruit extracts of Citrullus colocynthis Schrad. (Cucurbitaceae). The structures of the compounds were elucidated by spectroscopic analysis, mainly 1D and 2D NMR and comparing their physical (mp) and spectroscopic data with those reported in the literature. Compounds 1-5 were tested for their enzyme tyrosinase activity. The results showed that cucurbitacin E (2) (IC50= 1.99 :M) exhibited a more potent inhibition than the standard inhibitors kojic acid and L-mimosine. Keywords : CITRULLUS COLOCYNTHIS, TYROSINASE INHIBITION, CITRULLOSIDE, CUCURBITACIN

Istanbul Medipol University