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ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 4
A COMPARATIVE STUDY OF THE ESSENTIAL OIL FROM FLOWERS AND FRUITS OF LEPISANTHES RUBIGINOSA (ROXB.) LEENH
Department of Pharmaceutical Science, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand
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The essential oils extracted by hydrodistillation from the flowers and fruits of Lepisanthes rubiginosa (Roxb.) Leenh. were analyzed by capillary GC and GC-MS. The major components of the flower essential oil were nerolidol (34.8 %), palmitic acid (13.2 %) and farnesol (10.0 %). For the fruit essential oil, palmitic acid (66.1 %), myristic and (10.0 %) and linoleic acid (5.5 %) appeared to be the major constituents. Evaluation for in vitro anticancer activity of the essential oils was done against three human cancer cell lines (KB-Oral cavity cancer, MCF7 Breast cancer, NCI-H187 Small cell lung cancer). Only the flower essential oil exhibited anticancer activity against NCI-H187. Small cell lung cancer with the IC50 of 43.90 μgmL-1. The flower essential oil also possessed antioxidant activity (ABTS method) with the % inhibition of 25.4 %, whereas the fruit essential oil did not show anticancer activity and possessed low antioxidant activity with the % inhibition of 6.4 %. The flower and fruit essential oils exhibited strong antimicrobial activity against Trichophyton mentagophyte and showed moderately activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans.
Keywords :
LEPISANTHES RUBIGINOSA (ROXB ) LEENH, ESSENTIAL OIL, CHEMICAL CONSTITUENTS, ANTICANCER ACTIVITY, ANTIMICROBIAL ACTIVITY