ACTA Pharmaceutica Sciencia 2020 , Vol 58 , Num 3
The Pharmaceutical and Antimicrobial Properties of Dermatological Formulations Containing Hyptis Suaveolens (L.) Poit (Lamiaceae) Aerial Extract
Olusola I. Aremu 1-2 Tolulope O. Ajala 3 Isaac J. Ajeh 1 Kokonne E. Ekere 1
1 Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria
2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Ilorin, Kwara State, Nigeria
3 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Oyo State, Nigeria
DOI : 10.23893/1307-2080.APS.05820 The plant Hyptis suaveolens (L.) Poit (Lamiaceae) has received a lot of recognition because of its ethno-medicinal claims, some of which have been justified by scientific studies. The intention of this present work was to develop an antimicrobial dermatological dosage formulation. The powdered aerial extract was macerated in methanol for 72 h and the extract was formulated using vanishing cream base as vehicle at concentrations of 2.5, 5.0 and 7.5 % w/w respectively. The formulations were tested against selected microorganisms such as Staphylococcus aureus, Pseudomonas aeruginosa (Clinical isolates and standard strains), Trichophyton rubrum and Candida albicans. The results showed that activities against bacterial clinical isolates were not as encouraging as that of standard strains, while exhibiting significant concentration dependent antifungal activity (p<0.05) against the microorganisms tested with. This therefore shows potential for development as a standardized dosage form for the treatment of skin infections where the interrogated microorganisms are implicated. Keywords : Hyptis suaveolens, Aerial extract, Dermatological formulations, Antimicrobial properties

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