ACTA Pharmaceutica Sciencia 2020 , Vol 58 , Num 3
Exploring Irritant Activity of Some of the Phytochemical Components from Wild Sonchus arvensis (L.) ssp arvensis (D.C.) Kirp herb
Ayesha Asif 1 M. Asif Saeed 2
1 University of Central Punjab, Lahore, Pakistan
2 155, Mamdot Block, Mustafa Town, Lahore, Pakistan
DOI : 10.23893/1307-2080.APS.05817 Irritant activeness of sesquiterpene lactone glycosides, isolated from Sonchus arvensis (L.) ssp arvensis (D.C.) Kirp herb were investigated. These compound 1 to compound 7 were identified as sonchuside-E, sonchuside-F, sonchuside-G, sonchuside- H, sonchuside-I sonchuside-A and pirciside C. Such activity was appraised by open mouse ear assay, estimated by ID50. These sesquiterpene lactones exhibited well-defined irritant responses compared with euphorbium, used as reference compound. Compound-1 (sonchuside-E) appeared to be the most potent and persistent irritant with least ID50 whose reaction lasted for more than 48 hours. Compound-2 (sonchuside-F), Compound-3 (sonchuside-G), compound-5 (sonchuside-I) and compound-6 (sonchuside-A), revealed an irritant reactions of medium intensity while compound-4 (sonchuside-H) and compound-7 (pirciside C) displayed the least irritant and least persistent reaction. The likely mechanisms of their action were discussed. Keywords : Irritant activity, Sesquiterpene lactone glycosides, Sonchus arvensis

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