| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2020 , Vol 58 , Num 2
Microbiological and Histological Characteristics of Interactions Between Carvacrol and Fluconazole in a Systemic Candidiasis Animal Model
1 Department of Microbiology, Yasooj Branch, Islamic Azad University, Yasooj, Iran2 Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
3 Department of Biology, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran
DOI : 10.23893/1307-2080.APS.05811 Viewed : 17890 - Downloaded : 5027 The objectives of the study were to explore the effect of carvacrol on Candida tropicalis in vitro and in animal model, alone and in combination with fluconazole. The activity of carvacrol alone and in combination with fluconazole were tested on C. tropicalis using the CLSI reference method and in murine models. Carvacrol in combination with fluconazole showed satisfactory activity, with FICI mainly in the range of 0.375-1.00. Microbiologically, treatment with carvacrol alone in combination with fluconazole decreased the fungal load of kidneys of infected animal at negligible level of the number of colony counts of C. tropicalis. Histologically, in treated animals, no Candida organisms were found in the kidney tissues; this was in contrast to control groups in which many yeasts mixed with hyphae were observed. Carvacrol alone in combination with fluconazole as an alternative approach could be considered as the extensive opportunities for the treatment and prevention of systemic candidiasis. Keywords : Animal models; Candida tropicalis; Candidiasis; in vitro