ACTA Pharmaceutica Sciencia 2019 , Vol 57 , Num 1
Enhanced Solubility and Drug Release of Ketoprofen Using Lyophilized Bovine Serum Albumin Solid Dispersion
Meenakshi Bhatia 1 Rupa Devi 1
1 Guru Jambheshwar University of Science and Technology, Pharmaceutical Sciences, Hisar, India
DOI : 10.23893/1307-2080.APS.05703 Solid dispersions have been proved to be an effective method for the improvement of solubility and bioavailability of poorly water-soluble drugs. The study was designed to demonstrate the potential of ketoprofen loaded BSA solid dispersions on the solubility & in-vitro release of ketoprofen.

Ketoprofen-BSA solid dispersions were prepared by the freeze-drying method. A 2-factor, 3-level central composite experimental design was used to study the effect of varying concentration of BSA and ketoprofen on drug solubility & in-vitro drug release.

The combined effect of concentration of BSA & ketoprofen on % release and solubility exhibited a linear relationship between independent and dependent variables, suggesting that higher level of BSA & ketoprofen favours the expedited release and solubility.

Bovine serum albumin may be explored as a carrier for the preparation of solid dispersion for the enhancement of solubility and in-vitro drug release of BCS class II drug ketoprofen. Keywords : Bovine serum albumin, Ketoprofen, Solid dispersion, Lyophilization

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