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ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 4
A preliminary study on the synthesis and characterisation of dopamine-grafted block copolymers
1 Marmara University, Institute of Health Sciences, Department of Basic Pharmacy Sciences, Istanbul, Türkiye2 Bezmialem Vakif University, Institute of Life Sciences and Biotechnology Institute, Department of Biotechnology, Istanbul, Türkiye
3 Marmara University, Faculty of Pharmacy, Department of Basic Pharmacy Sciences, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6349 Viewed : 75 - Downloaded : 23 Biodegradable and biocompatible polymers are increasingly gaining importance in biomedical applications. Herein, we report the development of a thermoresponsive and tissue-adhesive platform based on a block copolymer of poly(N-isopropyl acrylamide) (P(NIPAM)) and polydopamine, synthesized via RAFT polymerization. Following the synthesis of P(NIPAM) homopolymer, P(NIPAM) was used as a macro-RAFT agent to incorporate the aldehyde block of the copolymer. The presence of aldehyde groups in the block copolymer was exploited to attach dopamine via imine chemistry. Spectroscopic and chromatographic techniques confirm the structures of intermediate compounds and polymers. The dopamine release profile of the copolymer was monitored for 72 hours at pH 7.4, and the total amount of dopamine released was found to be 53%. The synthesis of a dopamine-grafted block copolymer, which combines PNIPAM"s thermoresponsive properties with dopamine"s surface adhesion capabilities, suggests this platform could be a promising material for various future applications, such as implant interfaces and antimicrobial applications. Keywords : polydopamine, RAFT polymerization, biocompatible materials