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3 weeks |
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ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 3
Formulation of granules from Pleurotus ostreatus mushroom with potentialities for developing solid dosage forms
1 Universidad de Oriente, Faculty of Natural and Exact Sciences, Pharmacy Department, Santiago de Cuba, Cuba2 Universidad de Oriente, Center for Studies on Industrial Biotechnology (CEBI), Santiago de Cuba, Cuba
3 Universidad de Oriente, Faculty of Natural and Exact Sciences, Chemistry Department, Santiago de Cuba, Cuba
4 University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Department of Pharmaceutical Sciences, Antwerp, Belgium
DOI : 10.23893/1307-2080.APS6342 Viewed : 2589 - Downloaded : 997 The study was aimed to evaluate the potential of Pleurotus ostreatus granules as a raw material for developing solid dosage forms. Drug-excipient compatibility was assayed using 1:1 binary mixtures and the ratio of formulation components was optimised with a D-optimal design considering flow properties as response variables. Three batches of granules were produced with the optimised mixture by the wet granulation method. The quality of the granules was evaluated based on physical, rheological, chemical, and microbiological parameters. The concentration of phenolic compounds in the binary mixtures remained unchanged at 30°C, but decreased at 45°C and 60°C. Moreover, a quadratic model was used to fit the response variables. Mixing design allowed selecting the best excipient ratio. The granules showed a residual moisture content and a particle size lesser than 5% and 350 µm, respectively, as well as, excellent flow and compressibility properties, and optimal microbiological quality. Keywords : Pleurotus ostreatus, granules, phenolic compounds, flow properties, solid dosage forms