| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 3
Investigating the potential effects of thymoquinone on cisplatin-induced nausea and vomiting
1 KTO Karatay University, Faculty of Medicine, Department of Medical Biology, Konya, Türkiye2 NEU University, Faculty of Medicine, Konya, Türkiye
3 KTO Karatay University, Faculty of Medicine, Department of Anatomy, Konya, Türkiye
4 KTO Karatay University, Faculty of Medicine, Department of Histology and Embryology, Konya, Türkiye
DOI : 10.23893/1307-2080.APS6336 Viewed : 27 - Downloaded : 12 Cisplatin is a powerful chemotherapy drug used to treat certain types of cancer. The effects of this drug, nausea and vomiting, can reduce patients" quality of life and make it difficult to continue treatment. Thymoquinone is known to act on the gastrointestinal system. However, its effect on nausea is not clear. This study investigated the effects of thymoquinone on cisplatin-induced nausea. Animals were divided into four groups (control, cisplatin, thymoquinone, and cisplatin+thymoquinone). Cisplatin was administered intraperitoneally and thymoquinone by gavage. The amount of food consumed by the animals was recorded. In addition, gastrointestinal tissues were examined by hematoxylin and eosin (H&E) staining. The data obtained suggest that cisplatin causes damage to the gastrointestinal tract. However, it is possible that thymoquinone may contribute to the healing of this damage. Therefore, the addition of thymoquinone to patients undergoing chemotherapy has the potential to increase the effectiveness of the treatment process. Keywords : cisplatin, gastrointestinal system, pica, thymoquinone