| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 3
Antibacterial activity and UPLC analysis of Hypericum perforatum L. extracts
1 Istanbul Medipol University, Institute of Health Sciences, Istanbul, Türkiye2 Istanbul Medipol University, School of Medicine, Department of Medical Pharmacology, Istanbul, Türkiye
3 University of East London, School of Health, Sport and Bioscience, Department of Bioscience, Medicines Research Group, London, UK, United Kingdom
DOI : 10.23893/1307-2080.APS6334 Viewed : 26 - Downloaded : 10 Hypericum perforatum L. has been used for centuries as a herbal remedy against variety of diseases for its biological activities. It has been also used as an antibacterial agent against different bacteria. The aim of this study is to investigate the antibacterial properties of the H. perforatum L. extracts against several clinical isolates and explore their chemical composition. In terms of S. aureus strains, n-hexane extract demonstrated the best activity against XU212 strain, with the MIC of 256 µL/mL. The MIC was 512 µL/mL for other S. aureus strains for n-hexane and dichloromethane extracts. n-hexane extract demonstrated activity against E. coli ATCC 25922 with the MIC of 1 µL/mL. UPLC was performed for dichloromethane and methanol extracts. The main compounds were identified as catechin, hyperforin, and rutin from methanol extract, and hypericin and luteoskyrin from dichloromethane extract. S. aureus demonstrated good antibacterial activity against tested MRSA and Bacillus subtilis strains. Keywords : Hypericum perforatum L., extract, antibacterial activity, MRSA, UPLC