| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 2
Evolution of plasma trace element status in children treated with low-protein diets related to Maple Syrup Urine Disease (MSUD) and Urea Cycle Disorder (UCD)
1 Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, TürkiyeDOI : 10.23893/1307-2080.APS6325 Viewed : 3086 - Downloaded : 1219 The main treatment for Urea Cycle Disorder (UCD) and Maple syrup urine disease (MSUD) is low-protein diets and element deficiencies may develop related to dietary therapy. This study aimed to determine plasma trace element levels in patients with MSUD and UCD and to compare these results with those established in a healthy pediatric population not undergoing any dietary treatment. The study was conducted with 30 patients diagnosed with MSUD and UCD, and a control group of 30 health age-matched children. Dietary treatment involved a natural protein-restricted diet supplemented with a special formula, depending on the specific metabolic defect. Significant differences were observed between patients and control values for magnesium, selenium, and copper (p<0.05). These results reinforce that patients under dietary treatment should be regularly monitored for these elements. Furthermore, fortifying these elements in special formulas (as they are the sources of essential amino acids) should be considered. Keywords : trace element, children, MSUD, UCD, protein-restricted diet