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ACTA Pharmaceutica Sciencia
2006 , Vol 48 , Num 3
OPTIMIZATION OF DRUG-POLYMER MIXING RATIO IN ALBENDAZOLE-POLYVINYLPYRROLIDONE SOLID DISPERSION BY MOISTURE ABSORPTION STUDIES
Novel Drug Delivery Department, Ranbaxy Research Labs, Gurgaon, Haryana, India
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The main aim of the study was to investigate the moisture absorption behavior and the molecular mobility of albendazole-polyvinylpyrrolidone solid dispersions. Moisture gain magnitude of the dispersions was found to be significantly less compared to the amorphous physical mixture upon equilibration with 75% RH. Such decrease in moisture absorption magnitude was found to be high at 35-50% polymer content. The extent of plasticization of absorbed water was observed to be minimum at 50% polymer content. Therefore, the drug-polymer weight ratio was optimized to be 1:1 for obtaining the physically stable dispersion. Morphology of the solid dispersion of 1:1 drug-polymer mixing ratio was investigated using scanning electron microscopy. The tablets (equivalent to 400 mg of albendazole) formulated using this solid dispersion complied with the pharmacopoeial dissolution requirement.
Keywords :
ALBENDAZOLE, SOLID DISPERSION, MOISTURE ABSORPTION, PLASTICIZATION, CRYSTALLIZATION