| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 2
Neuroprotective effects of aminophylline in LPS-induced Alzheimer"s disease in rat model
1 Al-Nahrain University, College of Pharmacy, Department of Pharmacology, Baghdad, Iraq2 University of Warith Al-Anbiyaa, College of Medicine, Department of Pharmacology, Karbala, Iraq
DOI : 10.23893/1307-2080.APS6318 Viewed : 3361 - Downloaded : 1321 This research aimed to evaluate the aminophylline neuroprotective benefits against Alzheimer"s Disease -like characteristics caused by lipopolysaccharide (LPS) in forty rats divided into four groups: control group, induction group received lipopolysaccharide single dose once a day for seven days, third group received donepezil orally once daily for 21 days and fourth groups received aminophylline once daily for 21 days, and both third and fourth group received LPS once. The Barnes Maze behavioral parameters evaluated, inflammatory cytokines, and oxidative stress indicators were measured in brain tissue samples and the results showed that primary latency and primary error for the three phases of Barnes Maze behavioral test and the levels of studied inflammatory cytokines (IL-1b, IL-6, and TNFa) in addition to malondialdehyde (MDA) were reduced significantly in aminophylline group comparing with induction group while SOD1 levels increased significantly in aminophylline group comparing with induction group which indicate that aminophylline has neuroprotective effects via antioxidant and anti-inflammatory properties. Keywords : neuroprotective effects, aminophylline, LPS-induced Alzheimer"s disease